Hedgehog signalling: How cholesterol modulates the signal

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hedgehog signalling: How cholesterol modulates the signal

Developing embryos are replete with a variety of potent signalling proteins, the activities of which must be precisely regulated for development to follow its proper course. In principle, such signals may take two distinct forms. Proteins tethered to the membrane of a signalling cell — for instance via a transmembrane domain or lipid modification — might be expected to act as short-range switch...

متن کامل

Hedgehog signalling

The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extend...

متن کامل

hedgehog signalling pathway: carcinogenesis and targeted therapy

hedgehog signalling pathway has not only a critical role in cell proliferation, differentiation and tissue polarity at embryonic period but also has a vital role in stem cell proliferation, tissue healing and carcinogenesis. recent research has increased our understanding of this pathway and its relation to other signalling pathways. in addition, a large number of studies confirmed the alterati...

متن کامل

Transducing the Hedgehog Signal

ates Ptc from Smo (Figure 1B) is also generally enter-Daniel Kalderon* tained (Chen and Struhl, 1996) because it is countered Department of Biological Sciences only by a single observation of Ptc-mediated binding of Columbia University Hh to Smo in tissue culture cells that expressed high New York, New York 10027 levels of both vertebrate Ptc and Smo (Stone et al., 1996). Some new data support ...

متن کامل

Gli2, hedgehog and TCR signalling

A structurally and functionally diverse T-cell repertoire is essential for each of the key roles of the adaptive immune system: elimination of foreign pathogens, provision of immunological memory and the maintenance of tolerance to self. T-cells develop in the thymus and then migrate to the periphery where they undergo activation and functional differentiation following contact with cognate ant...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Current Biology

سال: 2000

ISSN: 0960-9822

DOI: 10.1016/s0960-9822(00)00346-8